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CircIL4R is significantly upregulated in HCC cells, and deletion of circIL4R has been shown to inhibit tumor growth in vivo (Xu et al., 2020)

Chow et al., 2019)

NOX4: a potential therapeutic target for pancreatic cancer and its mechanism

This was associated with a rise in lactate (starting hour 66), and alanine transaminase (ALT, starting hour 66) reflecting organ deterioration and eventual failure
