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Lessons from arthritis and cell therapy in cancer patients point to therapy for severe disease

Chemical method usually redundantly biotinylates a protein (left), whereas the enzymatic method specifically biotinylates a protein on its Avi-tag (right So, in cases where there is more than one cysteine present in a protein, researchers will often mutate out cysteine residues until there is only one left

These findings were not entirely concordant between the two studies, highlighting the need for replication in larger cohorts and drawing attention to methodological limitations such as modest sample sizes and lack of external validation

The microbiome as a key regulator of brain, behavior and immunity: commentary on the 2017 named series