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For example, certain types of peptide linkers are designed to be cleaved by enzymes abundant in tumor cells to selectively release drugs to these cells
In addition, in AD brain both 20S and 19S proteasomal complexes are targets of ox-PTMs, including the formation of HNE adducts, carbonylation, S -glutathionylation, glycoxidation, as well as ADP-ribosylation and phosphorylation (346, 355, 356)
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