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Moreover, assessing immunogenicity is complex, and such assessments should account for the detection of new drug-specific responses

The most frequent symptoms are: Developmental delays Anaemia Loss of appetite Chronic vomiting Weight loss Low brain volume Spasms/cramps Apathy Irritability In the most severe instance, vitamin B12 deficiency can lead to respiratory failures and coma (51)

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Experimental evidence has demonstrated that spontaneous neuronal activity in the parietal and frontal neocortex regions of Wistar rats was enhanced, as shown by an increased absolute neuronal discharge frequency
