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Teibel HM, Knoderer CA, Nichols KR
Furthermore, the same nucleosome/CCAN structure can also assemble without CENP-A, that is, on naked DNA (10), or with the H3 nucleosome (13), so the question of how exactly CENP-A specifically recruits CCAN is therefore still open
Early In Vivo Efficacy Studies: While safety is a top priority, conducting initial animal studies to assess if the drug has the desired therapeutic effect can be valuable alongside SP studies
We always ask about these conditions during our safety screening process
