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The randomization to sequences was stratified by sex and performed dynamically by the minimization technique using the dynamic allocation algorithm, second-best probability set to 15%, with the help of the Medidata-RTSM software
The parkinsonism producing neurotoxin MPP+ affects microtubule dynamics by acting as a destabilising factor
effects become more pronounced when infused into the bloodstream)
However, a deeper understanding of cereblon-based PROTACs is needed in various aspects, starting from their design and synthesis to their clinical evaluation
