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p = 0.063), also with high heterogeneity (I 2 = 87%)

Dean M, Park M, Le Beau MM, Robins TS, Diaz MO, Rowley JD, et al

well-tolerated in mice, rats, rabbits, and dogs with no serious organ toxicity.[34][35] Clinical Safety : Mild local irritation possible at injection sites, but no systemic adverse effects reported in trials.[36][37] Potential Risks : Theoretical concerns include pro-angiogenic effects potentially promoting tumor growth, though no evidence supports this in studies.[38] Long-term human data is limited, so monitoring is advised