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Key Content and Findings Physiology of copper metabolism Copper (Cu) is a trace element essential in electron transfer reaction which is required for cellular respiration including handling of oxygen and free radicals (2)
In many cell types, pyruvate carboxylation to oxaloacetate is suppressed, thereby rendering them reliant on glutamine catabolism to replenish the oxaloacetate that can condense with acetylCoA to produce citrate and drive the TCA cycle (DeBerardinis et al , 2007)
[DOI] [PMC free article] [PubMed] [Google Scholar] 446.Hurley D.J., Normile C., Irnaten M., OBrien C
