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158,159 The second step requires the activated NLRP3 oligomerization to recruit caspase-1 via ASC adaptor, ultimately leading to proteolytic cleavage of pro-IL-1 and pro-IL-18 into their active forms

[PubMed 7458498] 615

10.1038/s41590-018-0113-3 113 KopinL.LowensteinC

Combined indicator of vitamin B12 status: modification for missing biomarkers and folate status and recommendations for revised cut-points