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Interestingly, these iron accumulations can be remarkably alleviated by ferroptosis inhibitors, such as DFO (about 50%

Reduced iron in diabetic wounds: an oxidative stress-dependent role for STEAP3 in extracellular matrix deposition and remodeling
Multiple enzyme-like activities of GSH-CDs When environmental stress occurs, such as nutritional starvation and hypoxia, homeostasis in NPCs is out of balance, reflected by insufficient cellular antioxidant capacity and excessive ROS production [16]
