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Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappa B signaling cascade
Antioxidant systems like SOD and glutathione peroxidase (GPx) reduce OH generation by scavenging O 2 and HO, thereby lowering oxidative stress and inhibiting pyroptosis [232]
In the case of iron overload, the capacity of transferrin to bind iron becomes saturated, causing iron to accumulate as nontransferrin-bound iron (NTBI)
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