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Description
Lack of SMARCA4 inhibits expression of the aldehyde dehydrogenase ALDH16A1 that binds to the Trx1 active site and inhibits its function but also promotes lysosomal degradation of the redoxin [95]
BobrovnikovaMarjon E., Grigoriadou C., Pytel D., et al., PERK Promotes Cancer Cell Proliferation and Tumor Growth by Limiting Oxidative DNA Damage, Oncogene 29, no

We found that Dihexa-mediated protection requires activation of Akt, TOR, and MEK signaling, as inhibition of any of these targets attenuates Dihexa-mediated protection

The original research described it as a hepatocyte growth factor (HGF) mimetic with substantial potency in animal models of cognitive impairment
