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For EMT regulation involving multiple pathways and cell types, exploring polypharmacology or multi-drug regimens may improve intervention efficacy
However, in contrast to the 1 - and 2 -AR, earlier studies on the 3 -AR demonstrated that it does not appear to interact with GRKs or -Arrs, but rather it maintains resistance to classic clathrin-meditated endocytosis and downregulation (Curran and Fishman, 1996
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FIGURE 2 Xu et al
