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doi: 10.1371/journal.pone.0060394
Complementing this, PINK1-dependent mitophagy is upregulated during treatment to eliminate damaged mitochondria, preserve mitochondrial network integrity, and sustain both metabolic output and signal transduction fidelity [78]
We typically recommend a 24 week break after 812 weeks on for chronic protocols the necessity isn't fully established, but it's a sensible conservative approach for long-term use
High levels of oxidative stress may contribute to ALS onset, increasing motoneurons death, and heavy metals may be a cause for the increase of ROS
