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A., Angulo, P

In mitochondria, NAD + functions as an electron acceptor for NADH generated by glycolysis or the TCA cycle, thus transferring them to the respiratory chain [192]

The upregulation of Sirt3 protects against impaired electron transport and ATP production, loss of mitochondrial membrane potential (MMP) and neuronal vulnerability, and treatment with Sirt3 agonists can restore mitochondrial integrity, reduce S oligomers and oxidative stress

Consistency in your daily timing is more important than the precise minute you take them
