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This was demonstrated by increased levels of 8-hydroxy-2-deoxyguanosine (8OH2dG), a recognized biomarker for DNA oxidative damage, alongside the upregulation of pro-apoptotic genes such as Bax and p53, and a corresponding downregulation of the anti-apoptotic gene B cell lymphoma 2 (Bcl-2)

941 This excludes the cost of longterm nursing home care for individuals not eligible for Medicaid

Long-term deficiency of Vitamin B-12 can affect peripheral, spinal, and cognitive nerve function, explained bymethylcobalamin's role in the synthesis of the myelin sheath, the methylation of homocysteine, and the production ofvarious neurotransmitters, such as dopamine, norepinephrine, and synephrine