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This means that the ability of the transplanted cells to produce and secrete the correct matrix components is insufficient for long-term function, as the biomechanically indispensable architectural structures are difficult to form 56

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Senolytic therapies may eliminate senescent cells but may not fully resolve the long-term inflammatory consequences of their presence, while senomorphic agents may suppress the SASP but leave senescent cells intact, allowing them to persist and potentially cause harm.210 Combining both approaches addresses the complexity of senescence, offering a more holistic therapeutic strategy for aging-related conditions.45 Potential Applications of Combination Therapies The combination of senolytic and senomorphic therapies has broad potential applications in age-related diseases and conditions

& Deckert, M