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ALS-causing mutations significantly perturb the self-assembly and interaction with nucleic acid of the intrinsically disordered prion-like domain of TDP-43

Excessive drinking can result in serious health issues including: Increased risk of certain cancers Sudden death as a result of preexisting cardiovascular disease Heart muscle damage that leads to heart failure Stroke High blood pressure Liver disease Accidental serious injury or death Brain damage Overall, a person should not begin drinking for potential health benefits

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