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However, the majority of patients in literature presents in adolescence or adulthood with myopathy as first complaint [106]

It also reduced the protein expression of b-secretase, a key enzyme in driving amyloid aggregation and neurodegeneration

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Discussion Previous findings indicated pyruvate to contribute to growth of biofilms, with depletion of pyruvate or inactivation of lactate dehydrogenase impairing biofilm development and microcolony formation