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Dehydration is the most common cause of having very yellow or dark urine

10.1007/s13312-022-2594-2 57 TillemansM

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If oral B12 replacement has been trialled in a person with metformin-associated B12 deficiency, I would suggest that a repeat measurement of B12 levels after 812 weeks is a good time to reassess whether absorption is adequate or whether a switch to intramuscular replacement is required
