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In ALD, alcohol-induced dysbiosis increases LPS and ethanol translocation, accelerating hepatic fibrosis and steatosis via TLR4NF-B signaling

Transforming growth factor- (TGF-) is known to promote fibrosis and contribute to POF (Persani et al., 2011), and collagen content and fibroblast proliferation are significantly reduced, which is related to AMPK-mediated suppression of TGF- production after metformin administration (McCloskey et al., 2020)

Commonly implicated drugs that might precipitate or exacerbate RLS include antihistamines (particularly the sedating ones), selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs) and dopamine antagonists, such as metoclopramide

Currently, there is no known cure for IPF