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Tracheostomy: This procedure is nearly 100% effective at resolving obstructive events [95] but is reserved for patients with the most severe OSA who have failed all other therapies and exhibit life-threatening complications [96]

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Therefore, as an expected extension of the theoretical framework concerning adverse effects [1], the extensive model complexities and the involvement of a multitude of biological targets [129,130,131,132,133,134,135,136,137,138,139,140,141,142,168] should, axiomatically, be associated with the emergence of adverse outcomes