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Actually, Ustekinumab is a monoclonal immunoglobulin G1 antibody against IL-12 and IL-23, and Tocilizumab, an antagonistic antibody against the IL-6 receptor to inhibit IL-6 signaling, have demonstrated a marked clinical effect for autoimmune diseases, such as psoriatic arthritis and RA [116, 117]
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However, the clinical translation of PRLMs remains challenging
Khosla, S., Farr, J
