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40 reported that, in first-episode bipolar patients randomized to a year of lithium or quetiapine, those on lithium did better in every respect: fewer episodes of mania and depression, better functioning and cognition, and fewer abnormalities on brain imaging

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Possible contributing factors to muscle mass reduction and sarcopenia in liver cirrhosis include elevated serum ammonia, impaired protein synthesis, reduced anabolic hormones, and an inflammatory state in liver cirrhosis [18]