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Targeting mitochondria-inflammation circuit by beta-hydroxybutyrate mitigates HFpEF

Nucleolar stress promotes worm survival during starvation To survive under prolonged periods of starvation, animals often shift their metabolism to increased nutrient storage and efficiency of energy utilization

The activated IRE-1 upregulates the expression of a set of genes required for UPR LBS to restore the ER homeostasis
