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Although the combination of antibacterial and immunomodulatory activities of UA and OA may make them potential agents for TB adjuvant treatment, it is worth noting that high doses of UA and OA (2550 g/mL) are highly toxic to macrophages, the poor penetration, low lung concentration, and severe side effects caused by subcutaneous and oral administration of UA and OA may hinder the clinical application of these compounds to some extent

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