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Schultheiss et al., 2022

Standard research dose: 525mg/day oral Timing: Morning, pre-cardio or fasted Cycling: 812 weeks on / 4 weeks off is a reasonable protocol based on general NNMT inhibitor principles Form: Most sources provide capsules or powder

Clinical risk factors have been identified but genetic factors remain undiscovered

Among the most studied lipoperoxidation products, 4-hydroxy-2-nonenal, malondialdehyde, acrolein and F2-isoprostanes (eicosanoid molecules derived from the peroxidation of arachidonic acid found in biological membranes) represent good biomarkers of oxidative stress [79,80,81] and are measurable in biological fluids