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MOTS-c is a mitochondrial-derived peptide that translocates to the nucleus under metabolic stress, activating AMPK-dependent pathways that enhance glucose metabolism, fatty acid oxidation, and mitochondrial biogenesisthe core metabolic adaptations of endurance training

This low basal level of GSH in ARID1A-deficient ovarian and gastric cancer cells renders them sensitive to inhibition of GSH metabolism by Eprenetapopt 15,16

Long-term administration studies in animals suggest sustained improvements in body composition metrics without significant adverse effects

The 4-HNE is the breakdown product of the decomposition of polyunsaturated fatty acid peroxides that can be used as the biomarkers of lipid peroxidation and to detect oxidative stress damage (Hashimoto et al., 2003)