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Conflicts of interest: none declared References Morse,H.N (1878)Ueber eine neue Darstellungsmethode der Acetylamidophenole[on a new method of preparing acetylamidophenol].Berichte der deutschen chemischen Gesellschaft.11(1):232-233.doi:10.1002/cber.18780110151 Ayoub SS, Botting RM, Goorha S, et al Acetaminophen-induced hypothermia in mice is mediated by prostaglandin endoperoxide synthase 1 gene-derived protein.Proc Natl Acad Sci USA.2004;101:11165-11169 Schilling A, Corey R, Leonard M, Eghtesad B.Acetaminophen:old drug, new warnings

(2023) 4:e265

and berberine, documented to interact with the NRF2/ARE pathway (Shi et al., 2025

Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo