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For instance, in adrenocortical carcinoma IGF-1R inhibition with the kinase inhibitor NVP-AEW541 was found to induce compensatory activation of ERK and sustained mTOR activation, possibly via EGFR [79]

Deutz NE, Bauer JM, Barazzoni R, Biolo G, Boirie Y, Bosy-Westphal A, Cederholm T, Cruz-Jentoft A, Krznari Z, Nair KS, Singer P, Teta D, Tipton K, Calder PC

These observations suggest that neurons have a limited capacity to sustain high rates of glycolysis, warranting further investigation into whether neurons can enhance glycolytic rates under specific conditions
This arrangement may prevent access of reactive fragments to susceptible groups within the vicinity of the active site
