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Interleukin-1 Interleukin-1 (IL-1) is markedly elevated in intestinal mucosa under inflammatory conditions, such as CD patients.44 In clinical studies, an IL-1 receptor antagonist is currently being developed for therapeutic usage, which indicates IL-1 plays a central role in the intestinal inflammatory process.45 Furthermore, recent studies show that IL-1 causes increased intestinal TJ permeability

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