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Whiteflies fed on CypB dsRNA-expressing plants died earlier than those fed on pTV::Bt Hsp70 , TRV alone and mock inoculated plants, thus we were not able to test the effect on following generations

At the molecular level, apigenin regulates several critical cell signaling cascades, such as Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-B), Phosphoinositide 3-Kinase/Protein Kinase B (PI3K/Akt), and Mitogen-Activated Protein Kinase (MAPK), thereby mitigating inflammatory responses and oxidative stress [102]

Another recurring limitation emerges on antioxidant-based interventions in ASD, constrained by a fundamental methodological gap: most clinical studies report behavioral or functional improvements without directly measuring oxidative-stress biomarkers