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doi:10.1046/j.1440-1746.2003.03165.x

Brain and body disconnect: A retrospective case series of subacute combined degeneration of the spinal cord from chronic nitrous oxide use

This is not included with the cost of the medication

The FDA placed it in Category 2, which means it presents significant safety concerns including immunogenicity the risk that your own immune system mounts a response against it
