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research combining both should proceed cautiously

Pietras A, Katz AM, Ekstrm EJ, Wee B, Halliday JJ, Pitter KL, et al

Relevant maternal, perinatal, and developmental histories were obtained from medical records and structured parent interviews

The TME is a complex and multi-layered structure, primarily consisting of cancer cells, cancer-associated fibroblasts (CAFs), cells that suppress the immune system (such as tumor-associated macrophages [TAMs], myeloid-derived suppressor cells [MDSCs], and regulatory T cells), cells that activate the immune system (including natural killer [NK] cells, dendritic cells [DCs], and T cells), and a variety of signaling molecules [33,34,35,36]