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The results are in support of a growing body of research indicating that the omega-3 fatty acid EPA can help regulate mood and depressive symptoms, even in otherwise healthy adults without clinical depression [47, 48]

Since mitochondrial NADH carries a deupleted proton (which is delivered to the intermembrane space by NADH dehydrogenase), the proton in NADPH will also be deupleted (Seneff and Kyriakopoulos, 2025a)

7.3 Development of combined intervention strategies The revised section now discusses the potential of combined therapeutic approaches, such as the co-administration of natural bioactive compounds with probiotics or prebiotics, to synergistically regulate gut microbiota composition, restore intestinal barrier integrity, and reduce hepatic oxidative stress and inflammation