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The result is a marketing layer that sounds substantive but doesn't tell you what's actually known, what's well-established, or where the gaps are
353 These findings confirm that in the synovium, GLP-1R is expressed on two different cell types, macrophages and fibroblast-like synoviocytes, which are specialized cells distributed within the synovial intima and subintima, and these cell types play important roles in hyaluronic acid synthesis, metabolite processing, and clearance of matrix degradation fragments
The mechanisms driving central sensitization include elevated substance P, reduced descending pain inhibition, altered glutamate signaling, and microglial activation in the central nervous system
Frequency depends on the clinical reason for treatment
