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Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohns disease: a prospective, multicentre, cohort study

Thats why fatigue, brain fog, and low motivation are common symptoms of deficiency

Possible side effects include: headache, flushing (warmth or redness of the face), dizziness or light-headedness, nausea, or transient fatigue/somnolence