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LBA49 mRNA-4157 (V940) individualized neoantigen therapy + pembrolizumab vs pembrolizumab in high-risk resected melanoma: clinical efficacy and correlates of response
a separate Merck Phase 2b trial in hip-fracture patients (Adunsky et al., 2011, PMID 21067829) was stopped early after a cardiac safety signal emerged
The compound activates HGF/c-Met signaling in hippocampal and cortical regions at picomolar to nanomolar concentrations, suggesting efficient distribution to the brain regions most relevant to learning and memory
[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Zhang J.-X., Guo L.-Y., Feng L., Jiang W.-D., Kuang S.-Y., Liu Y., Hu K., Jiang J., Li S.-H., Tang L., et al
