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Do Local Tobacco-21 Laws Reduce Smoking Among 18 to 20 Year-Olds

30 Nicotine is metabolized primarily to cotinine, which is further metabolized to trans-3-hydroxycotinine (3HC), catalyzed by the liver cytochrome P450 2A6 enzyme

Nicotine: The heart of the product
Blood Cancers TS is not a risk factor for the risk of malignancies, but some epidemiological evidence supports the claim that TS is a risk factor for leukemia [64]
