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The mean tetranor-PGDM concentrations in patients with the typical phenotype (mean 5.3 2.8, median 4.2, range 2.322.7) were 1.6-fold higher than those of the healthy controls ( p = 0.007) and 2.3-fold higher than those of the patients with the mild phenotype ( p = 0.002

These studies should incorporate standardized oxidative stress measurements, clear inclusion criteria, adequate sample sizes, and long-term follow-up to provide conclusive guidance for clinical practice

Levels of serum Immunoglobulin M (IgM), Human -Defensin 2 (HD2) and GSH were assessed at baseline and 24, 72, 120 hours after intervention

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