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Food and Drug Administration (FDA) for the treatment of individuals with type 2 diabetes (T2D) and obesity, glucagon-like peptide-1 receptor agonists (GLP-1RAs) such as semaglutide and liraglutide significantly improved body weight in patients with T2D while reducing glycated haemoglobin (HbA1c) levels in these patients [3, 4]

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Glinides are insulin secretagogues that lack the sulfamide group of the sulfonylureas and differ from sulfonylureas in receptor affinity, binding sites, duration of action and mechanism of absorption and elimination ( According to data from several meta-analyses, an overall increased cancer risk was reported in patient using sulfonylureas compared with those treated with metformin or other diabetes medications (Wu et al., 2015

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