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Description
We show that the cardioprotective actions of GLP-1(2836) do not depend on a functional transmembrane GLP-1R but rather are mediated intracellularly through type 10 soluble adenylyl cyclase (sAC), accompanied by increased cAMP levels, protein kinase A (PKA) activation, and endothelial nitric oxide synthase (eNOS) phosphorylation
GLP-1s (glucagon-like peptide-1 receptor agonists) mimic a hormone naturally produced in your gut
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Genetic factors also play a role
