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These typically occur in more than 5% of patients and are usually mild to moderate in severity
Consumer reviews show mixed results, with many reporting skin irritation and no weight change
While nearly three-quarters of the suspect shipments that PSM found were allowed into the country, one of the rejected shipments contained over 30 pounds of tirzepatide, the active pharmaceutical ingredient in Mounjaro and Zepbound
These effects subsequently trigger hyperactive innate immune responses via MyD88/TLR4-dependent signaling pathways, ultimately aggravating colitis progression [138]
