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Both compounds improve insulin sensitivity, but through partially overlapping and partially distinct mechanisms

In June 2023, the American Society of Anesthesiologists (ASA) guidance suggested that patients anticipating anaesthesia discontinue short-acting GLP-1 RAs for 1 day and long-acting GLP-1 RAs for 1 week, while observing standard ASA fasting guidelines

A more clinically relevant consideration is the risk of low blood sugar (hypoglycemia) when combining these medications

These trials are crucial in determining whether GLP-1 drugs can provide long-term weight management benefits beyond their original use for type 2 diabetes