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Description
Some individuals may experience mild side effects as their body adjusts to tirzepatide, especially during the first few weeks of treatment

Hormonal disorders such as untreated hypothyroidism, Cushing's syndrome, or polycystic ovary syndrome (PCOS) can impair metabolic responses to semaglutide

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Nicotine activates GLP-1 neurons in the hindbrain, raising endogenous GLP-1 reduces nicotine taking, and acute nicotine lowers circulating GLP-1 (Tuesta et al., 2017