glp-1 vs metformin Clinical Focus on Agonists in Type 2 Diabetes Mellitus Metformin vs. GLP-1 Receptor Agonists:

[DOI] [PMC free article] [PubMed] 46.Collins L, Costello R

In this Point-Counterpoint, we argue that it is time to apply the modern concepts of clinical practice to diabetes management and base therapy on pathophysiology

In addition, DPP-4i can alleviate vascular inflammation in hypertension by regulating inflammatory responses and improving vascular endothelial function, thereby reducing the incidence of cardiovascular complications

It is noteworthy that this superior effectiveness extended to primates (humans and cynomolgus monkeys) and rodent models of obesity and diabetes, such as db/db (diabetic) mice and Zucker diabetic fatty (ZDF) rat