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Lancet Diabetes Endocrinol 6(4):275286 [DOI] [PubMed] [Google Scholar] Rossing P, Baeres FMM, Bakris G, Bosch-Traberg H, Gislum M, Gough SCL et al (2023) The rationale, design and baseline data of FLOW, a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease

Tips for Staying Hydrated : Aim for at least eight glasses of water daily Incorporate hydrating foods like cucumbers, watermelon, and citrus fruits Avoid sugary drinks, alcohol, and excessive caffeine Instead of reaching for sodas or sugary beverages, consider flavoring your water with fresh fruit or herbs like mint and basil

[4] Sleep hygiene is crucial

Trial Metric Retatrutide 12mg (TRIUMPH-4) Semaglutide 2.4mg (STEP 1) Mean Weight Loss 28.7% at 68 weeks 14.9% at 68 weeks Mechanism Triple agonist (GLP-1/GIP/GCGR) Single agonist (GLP-1) FDA Status Phase 3 (investigational) Approved (Wegovy) Dosing Weekly subcutaneous Weekly subcutaneous Common Adverse Events GI (nausea, vomiting, diarrhea), dysesthesia GI (nausea, vomiting, diarrhea) Important caveat: These results come from different trial populations and study designs