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Substituting three residues in the flexible N terminus of GLP-1 by corresponding PACAP residues (Ala 8 Ser/Glu 9 Asp/Thr 11 Ile) does not affect affinity and potency for GLP-1R (Xiao et al., 2001), implying that GLP-1 adopts a similar conformation to PACAP upon binding to its receptor
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From the Lab Related Blog Posts Apr 13, 2026 About blank
