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It is proposed that GLP-1 signaling may enhance mitochondrial biogenesis through the PGC-1/nuclear respiratory factor-1/mitochondrial transcription factor A pathway, regulated by adiponectin/AMP-activated protein kinase (AMPK), and increase the expression of NAD-dependent protein deacetylase sirtuin 1 (SIRT1), which upregulates Parkin expression, thereby promoting mitophagy [37]
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