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In a 2-year carcinogenicity study in Sprague Dawley rats, subcutaneous doses of 0.0025, 0.01, 0.025 and 0.1 mg/kg/day were administered (below quantification, 0.8-, 1.8- and 11-fold the exposure at the MRHD)

The discovery in Northampton led to the largest single seizure of trafficked weight-loss drugs ever recorded by a law enforcement agency worldwide, according to the MHRA

The United States Food and Drug Administration (FDA) approved it to treat obesity